What we help with

The conditions behind “I’ve tried everything.”

If you’ve tried several approaches without a clear answer, one possibility is that the pieces have never been evaluated together.

The most common reasons patients arrive at Twin Cities Metabolism — and how we evaluate the cascade behind each one before recommending a single intervention.

Open to the public No referral required Functional medicine evaluation

Eight common entry points

What we actually work on.

Each card is a case profile — the diagnostic frame, the markers we run, the questions we’re answering. Click any to see the cascade.

WHEN THE SAME PROTOCOLS STOP WORKING
Weight Loss Resistance
Adaptive thermogenesis, blunted satiety, post-diet downshift. Tested through metabolic rate, body composition, and hormonal markers — not the scale alone.
WHEN THE METABOLISM STOPS RESPONDING
Metabolic Damage
Years of chronic dieting blunt the engine. We measure RMR, T3/rT3, and the downstream signaling that explains why “eat less, move more” stopped working.
BEYOND THE TSH-ONLY SCREEN
Low Thyroid + Hashimoto’s
Nine thyroid markers, not one. Free T3, reverse T3, TPO and Tg antibodies. The full pathway tells the story TSH alone never can.
THE METABOLIC ROOT OF CYCLE DISORDERS
Insulin Resistance + PCOS
Fasting insulin, HOMA-IR, A1c, androgens — read together. Metabolic and cycle questions overlap; we measure the metabolic side so you know which question is actually yours.
SEX HORMONES · HPA AXIS · METABOLITES
Hormone Imbalance
DUTCH-evaluated. We see the full hormone cascade — estrogen metabolites, cortisol slope, progesterone — not just one reading of one molecule.
MULTI-AXIS EVALUATION, NOT JUST HRT vs. NO HRT
Perimenopause + Menopause
Estrogen, progesterone, thyroid, adrenals, metabolic markers. The 40+ transition is a system shift — we evaluate it that way.
GUT TESTING THAT ACTUALLY TELLS YOU SOMETHING
Food Intolerance, IBS & Food Reactions
GI-MAP stool. Lactulose/mannitol intestinal permeability. SIBO breath test. Each test answers a different question — matched to yours, not stacked.
PROTECTING MUSCLE WHILE THE WEIGHT COMES OFF
Working With GLP-1s
Body composition (InBody), resting metabolic rate, and the labs that help you keep muscle and metabolic rate while the weight comes off.

A different way of looking at conditions

Most chronic conditions are cascades, not categories.

Conventional care names conditions by their loudest symptom: low thyroid, PCOS, perimenopause, IBS. Useful labels — but they hide a more important truth.

In our clinic, almost every patient we see has two or three of these conditions at once, driven by an overlapping set of upstream causes: gut dysfunction, undertreated thyroid, HPA axis stress, insulin resistance, hormonal disruption, hidden inflammation. The label changes; the underlying physiology often doesn’t.

That’s why our evaluation starts with the cascade — not the diagnosis. We measure first. The data helps narrow the priorities before a protocol is chosen.



The same six metabolic drivers produce eight different condition labels

Six areas we can examine

  • Gut and microbiome
  • Cortisol and stress patterns
  • Insulin resistance
  • Hormone-related patterns
  • Thyroid function
  • Inflammation

These areas can overlap and appear under different symptom or diagnosis labels.

  • Weight-loss resistance
  • Metabolic adaptation
  • Low thyroid
  • Insulin resistance and PCOS
  • Hormone symptoms
  • Perimenopause
  • Food intolerance and IBS
  • GLP-1 support

Illustrative — a symptom or diagnosis label does not identify which area is relevant for one person or establish causation.


Still not sure which fits?

None of these sound quite like you?

Answer a few quick questions and we’ll point you to the right starting point in about 90 seconds — no reading required.

Find your path →


Why measure with us?

A lab-testing app hands you a hundred numbers. A national telehealth membership gives you video visits. We measure what they can’t — your actual resting metabolism and body composition — read every marker as one connected story, build the plan with you, and re-test to measure whether it’s working.

Lab-based testing runs the same locally or nationwide; resting metabolism and body composition are measured in our Roseville clinic.


“Jared’s knowledge is mind-blowing and he isn’t trying to sell you on any cookie-cutter products or packages or workout routines, he is helping you understand how YOUR body works… A test result may look normal to your normal doctor, but Jared can look at the ranges within the normal ranges and help you understand how YOUR body is working.”

— Tammy B., Google review

Individual results vary.


Medically reviewed by Dr. Jared Larsen, LN, CNS, DC, MS.